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Scientific Research

The idea that more “research is needed” for electronic cigarettes is quickly becoming a thing of the past. We compiled some of the best and most pertinent research here to answer the critical questions. The quotes found here are from researchers and doctors, and several research papers are provided in their entirety.


Will I get the nicotine I crave with electronic cigarettes? How much nicotine will I get?

The Clinical Trials Research Unit at The University of Auckland, New Zealand conducted a highly respected scientific study to assess the ability of an electronic cigarette to suppress desire to smoke and reduce withdrawal symptoms. The study was conducted on participants who had no intention to quit smoking prior to trials. Their study was validated with ethical approval from the New Zealand Ministry of Health’s Northern Y Ethics Committee (approval number NTY/07/10/109, no conflicts of interest found). The inhalator quoted in the study was a commercially-purchased Nicorette inhalator. We pulled some highlights from the study as follows:

"The Ruyan 16 mg nicotine Electronic Nicotine Delivery Device reduces desire to smoke."

"These findings suggest potential to help people stop smoking in the same way as a nicotine inhalator."

"The 16 mg Electronic Nicotine Delivery Device rated higher for pleasantness of use than the inhalator"

The study statistically found that 10 minutes after using the Electronic Nicotine Delivery Device a user's desire to smoke was reduced by 60% as compared to when they had smoked a real cigarette. 60 minutes following use, desire to smoke was nearly identical for the Electronic Nicotine Delivery Device, a real cigarette, and the inhalator.

"Electronic Nicotine Delivery Devices were more pleasant to use than inhalator and produced less irritation of mouth and throat."

"There was no difference in withdrawal symptoms between the 16 mg Electronic Nicotine Delivery Device and inhalator, whereas usual cigarettes reduced withdrawal ratings more on all items than the other products."

"The 16 mg Electronic Nicotine Delivery Device was favored over other products for enabling participants to keep from smoking, to be used as a potential quitting aid and for recommending to a friend who wanted to stop smoking."

"The 16 mg Ruyan V8 Electronic Nicotine Delivery Device alleviated desire to smoke after overnight abstinence, was well tolerated and had a pharmacokinetic profile more like the Nicorette inhalator than a tobacco cigarette."

To view the entire article for yourself, here is a link to the Research Paper.

Are electronic cigarettes deadly and carcinogenic like tobacco cigarettes? Does second-hand vapor affect bystanders?

The most recent study for air quality risk analysis was performed by CHANGE, LLC at the Center for Air Resources Engineering and Science at Clarkson University in Potsdam, NY. The study was published in the peer reviewed journal Inhalation Toxicology. The few compounds that were found were at such minuscule levels that toxicology analysis detected no risk (cancer or non-cancer risk) to public health from environmental e-cigarette vapor.

Upon review of this recent study: “While secondhand smoke must be eliminated in workplaces and public places, the current data provide no justification for eliminating electronic cigarette use in these places.”- Dr. Michael Siegel of Boston University School of Public Health

“For more than 25 years, Smokefree Pennsylvania has been advocating indoor smoking bans. Based on the results of this study I see no reason for e-cigarettes to be included in smoking bans.” - Bill Godshall of Smokefree Pennsylvania

“The results of this study confirm the findings of my last 4 years of research. E-cigarettes pose no discernible risk to public health." - Dr. Murray Laugesen - Public Health Medicine Specialist, Health New Zealand

To read the press release for this study here

To view the abstract for the study click here

"Electronic cigarettes and other nicotine-containing devices offer massive potential to improve public health, by providing smokers with a much safer alternative to tobacco. They need to be widely available, and affordable to smokers." - Professor John Britton, chair of the Royal College of Physicians Tobacco Advisory Group

What’s in e-liquid?

Dr. Michael Siegel of Boston University School of Public Health wrote an article on Harm Reduction Strategy which was published in the Journal of Public Health Policy on Dec 9, 2010. He reviewed 16 studies which identified the contents of e-liquid in several different brands of electronic cigarette cartridges. Quotes from his article are as follows:

“We were able to identify 16 studies that have characterized, quite extensively, the components contained in electronic cigarette liquid and vapor using gas chromatography mass spectrometry (GC-MS) (Table 1). These studies demonstrate that the primary components of electronic cigarette cartridges are propylene glycol (PG), glycerin, and nicotine.”

“Thus far, none of the more than 10,000 chemicals present in tobacco smoke, including over 40 known carcinogens, has been shown to be present in the cartridges or vapor of electronic cigarettes in anything greater than trace quantities.”

“No one has reported adverse effects, although this product has been on the market for more than 3 years.”

“The maximum level of total TSNAs reported was 8.2 ng/g.6 This compares with a similar level of 8.0 ng in a nicotine patch, and it is orders of magnitude lower than TSNA levels in regular cigarettes.”

“…a preponderance of the available evidence shows them to be much safer than tobacco cigarettes and comparable in toxicity to conventional nicotine replacement products.” [NicoDerm CQ patch]

To read all of his findings, here is a link to the Full Article.